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If you’re just using it to declare packages and some configs then yeah you could definitely run like a post-install script or something on top of a minimal distro. I’ve done this for a while when i was using Void. It’s get trickier though when you consider that nix can also lock your config at a specific version of all the software you have installed, which i don’t think can easily be done on the average distro. There’s also the rollbacks, though i suppose you could use btrfs for that, but i’ve never tried it.
with DNF you can specify a specific version I assume the same is true for other packages. Proper backup solutions should give the same A/B upgrade path that Nix and other immutable distros enjoy. I like nix I really do I just would like to have a reason to go through the painful learning process.