From what I understand, biological systems regulated by sex hormones require one or the other to work at all. For example, you get one pattern of post-puberty bone growth with estrogen, a different pattern with testosterone, and no bone growth at all if you have neither. These systems also have some counterbalancing factor, like your bones constantly being slowly dissolved to keep calcium in your bloodstream, so if you have no gonads and no supplementary hormones, you essentially speedrun osteoporosis over the course of a few years.
I’m not too clear on other effects, but a lot of things are downstream of “your bones slowly melt,” and lots of other parts of your body rely on sex hormones to regulate them and will have long-term issues without them.
Israel’s entire edge in the tech sector is in lax regulation and a steady supply of experienced, amoral ex-military software engineers. Western entrepeneurs who would otherwise have had trouble finding willing professionals and maintaining legal cover for their adware, data mining, or cyberweapons startup in a home country more concerned with ethics and international relations flocked to Israel over the last couple decades and singlehandedly propped up the local economy.
In return, the US, for instance, gets to wash its hands of the whole affair and say they’re not the ones selling spyware to the Saudis and other western-friendly authoritarian regimes, it’s all out of their control, while American venture capital reaps the rewards of investments in Israeli companies.