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The mainboards work stand-alone. There are free STLs to print a case for it or you can buy a case from them.
Basically replacing the mainboard gives you another small PC to use as a desktop/living room/server device. You obviously still need RAM and storage though.
I own a framework 13 and I replaced the mainboard once (due to an issue, they replaced it) and it took less than 10 minutes to swap. It’s expensive for what it is, but in support of their vision I was willing to pay premium for it.
They also argue that they need these high prices due to low volumes with the goal of bringing prices down to be more competitive eventually.