It depends on what you want to run.

Games generally run very well or even better than windows, but if your target is games you should use a more “optimized” verison of wine, like proton. Other applications are a bit of a hit or miss: things like MS office, adobe trash, etc. don’t run very well if at all, some may have random issues like crashes or the UI not working properly, others run perfectly, you have to try it.

If you run into issues, don’t be discouraged: for games, take a look at protondb.com or PCGW (fixes that work on windows usually work on wine too), for applications, check the appdb on winehq.org; when something doesn’t work more often than not it’s just a missing library or some setting you have to tweak.